Rams wideouts Cooper Kupp and Puka Nacua, along with 49ers weapons Christian McCaffrey and Deebo Samuel are some of the high-profile names that are going to miss Week 3 and beyond. Along with them, injury questions surround Jordan Love, who is dealing with a knee injury, and Justin Herbert, who has a balky ankle.

Nine of 32 teams remain unbeaten entering Week 3. The esteemed group: The Bills, Buccaneers, Chargers, Chiefs, Saints, Seahawks, Steelers, Texans and Vikings. At least two of these teams will have their perfect records soiled this weekend, because the schedule features two games between undefeated teams: Texans at Vikings and Chargers at Steelers.