No Kittle means the 49ers will be down three All-Pros on offense. The club figured to rely heavily on him while McCaffrey and Samuel were out. Now it appears Eric Saubert and Jake Tonges are in line for tight end snaps if Kittle is unable to play in Week 3.

By NFL rule, the 49ers should have let the league know what the status of injured running back Christian McCaffrey would be before the weekend. The team apparently thought that McCaffrey might be ready to go on Monday night against the Jets, and did not rule him out until about an hour-and-a-half before kickoff of their Week 1 opener.

Injuries can make or break your fantasy season. Here is the latest news on the NFL's biggest stars with injury questions heading into Week 3.

The San Francisco 49ers started off Week 3 on the right foot. After absences and limited participations littered their first six practice participation reports, Wednesday’s report was relatively empty. Wide receiver Deebo Samuel was a non-participant as expected. Every other player was a full go to kick off Week 3’s practices.

The Atlanta Falcons returned to the practice field on Thursday to prepare for this weekend's prime-time matchup against the Kansas City Chiefs. The Chiefs lost running back Isiah Pacheco to a broken fibula in their Week 2 win over the Bengals,

The list of issues thus far for the Rams is probably as long as their injury report. Sean McVay is staring at a “depth” chart ravaged by injuries. Eleven Rams are already on the IR. It was expected that list would reach an even dozen but LA has decided not to place Cooper Kupp (ankle) on the IR.

The San Francisco 49ers received more bad injury news Thursday, as George Kittle and Charvarius Ward both sat out of practice in Santa Clara.

The San Francisco 49ers have added defensive end Nick Bosa on the injury report ahead of their Week 3 matchup against the Rams. While the team hasn’t yet mentioned if he will play versus the Rams, Bosa was a limited participant in this week’s practice.

Dotson was the only player to practice Wednesday. The guard was limited in reps but was able to participate despite his foot injury. Dotson was among several players who sustained injuries in the season opener.