The San Francisco 49ers picked up their first loss of the season, falling 23-17 to the Minnesota Vikings in Week 2. A special teams error, two turnovers (interception and fumble) and two turnovers ...

The already-depleted San Francisco 49ers offense took another hit, as another key player is set to miss some time. 49ers head coach Kyle Shanahan told reporters on Monday that star receiver Deebo ...

San Francisco 49ers running back Christian McCaffrey is going to be out for at least the next four games. Per ESPN's Adam Schefter, the 49ers will place the reigning NFC Offensive Player of the ...

The San Francisco 49ers take their 1-0 record to the road against the Minnesota Vikings on Sunday. San Francisco easily took care of the Aaron Rodgers and the New York Jets at home in the season ...

The San Francisco 49ers recently navigated a tumultuous period involving wide receiver Brandon Aiyuk, who initially sought a trade but ultimately secured a new contract with the team. The ...

The San Francisco 49ers have one of the most well-built rosters in football. San Francisco made a run to the Super Bowl last season, although it ended up losing to the Kansas City Chiefs.

The San Francisco 49ers are dealing with another notable injury. The 49ers, who recently put All-Pro running back Christian McCaffrey on injured reserve, will also be without receiver Deebo Samuel ...

Amid the offseason uncertainty surrounding Brandon Aiyuk, the 49ers checked in on Justin Jefferson's availability before this year's NFL draft, but the Vikings had zero interest in trading the ...

MINNEAPOLIS -- The San Francisco 49ers placed star running back Christian McCaffrey on injured reserve with calf soreness and Achilles tendinitis, the team announced Saturday. McCaffrey must miss ...

Suddenly the 49ers have just one healthy running back they trust. Christian McCaffrey has Achilles tendonitis and could go to the Injured Reserve List soon. And Elijah Mitchell already is out for ...