Deebo Samuel is slated to play Sunday versus the Buccaneers after being listed as questionable with rib and oblique injuries, per NFL Network Insider Ian Rapoport.

The 49ers activated running back Christian McCaffrey from injured reserve Saturday, setting up his season debut on Sunday vs.

John Lynch revealed what Christian McCaffrey's impending return might mean for backup San Francisco 49ers running backs Jordan Mason and Isaac Guerendo.

NFL trade deadline day didn’t disappoint. While the hot stove burned for weeks — headlined by deals for marquee players ...

He fell back down the depth chart in Houston ... either a wide receiver to replace Brandon Aiyuk or a running back to help as ...

Aside from obvious outliers like Nick Bosa or to an extent Brandon Aiyuk, it's not often that 49ers fans find themselves ...

From starting QBs to standout wide receivers, teams are looking further and further down their depth charts entering Week 9 ... The star San Francisco 49ers running back has not played yet this year, ...

WR Jalen McMillan was already considered a starter in three-receiver sets for the Bucs, but with Chris Godwin and Mike Evans out the rookie became the team's most active wideout ...

San Francisco 49ers rookie running back Isaac Guerendo’s coachability and maturity has played a big role in his steady ...

In Week 8, the four-time Pro Bowler will get a chance to prove that he can still be an effective NFL running back. Cook was signed to Dallas' practice squad after remaining unsigned during the ...